产品货号：
Z21327
中文名称：
MYO6抗体
英文名称：
Anti-MYO6 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MYO6 Antibody |
| 指标别名 | DFNA22;DFNB37;KIAA0389;MYO6;myosin VI;Unconventional myosin 6 |
| 克隆性 | Polyclonal |
| 检验物种 | human,pig |
| 应用范围 | SDS-PAGE,WB |
| 基因名称 | MYO6 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-Myosin-6 was prepared from whole rabbit serum produced by repeated immunizations with full length myosin-6 construct expressed in SF9 insect cells corresponding to porcine myosyn-6 protein. |
| 计算分子量 | 150kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | Anti-Myosin-6 is directed against the myosin-6 protein.The product was prepared from monospecific antiserum by delipidation and defibrination.A BLAST analysis was used to suggest reactivity with 94% human Myosin VI.Cross-reactivity with myosin6 from other sources have not been determined. |
| 浓度 | 25mg/mL by Refractometry |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Myosin VI is a myosin superfamily member with unique and intriguing features that allow it to fill a still-expanding number of cell biological roles.This actin-based motor produces force that acts towards the minus end of actin filaments,which is the opposite direction to all other characterized myosins.In mammalian cells,myosin VI is localized to endocytic vesicles,membrane ruffles,the cytosol and the Golgi complex.Its motor function is essential for several physiological functions of the cell,including normal rates of endocytosis,maintenance of Golgi morphology and protein secretion.Myosin VI regulates epithelial cell migration and plays a role in the maintenance of adhesive cellular contacts within epithelial cell layers.It is highly expressed in ovarian cancers and prostate cancers and its expression level,which is upregulated by DNA damage in a p53-dependent manner,correlates with the potential of the tumor to disseminate.More recently,myosin VI has been found involved in EGFR endocytosis through a clathrin dependent mechanism. |
| Uniprot ID | Q29122 |
| 基因名全称 | Unconventional myosin-VI |
| 推荐稀释比 | ELISA:1:10,000 WB:1:1000 |
相关搜索：MYO6抗体，MYO6多抗，Anti-MYO6 Antibody